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Author Topic: What stage of liver damage for risk of cancer?  (Read 8749 times)

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Offline strangerbynight

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  • Posts: 111
What stage of liver damage for risk of cancer?
« on: July 27, 2017, 11:25:53 pm »
So what stage of the liver damage to have a risk for cancer? Is it only for F4 with cirrhosis or could it be any stage?

Offline Lynn K

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Re: What stage of liver damage for risk of cancer?
« Reply #1 on: July 28, 2017, 12:01:17 am »
Primarily F4 cirrhosis but I am guessing maybe F3 being near cirrhosis could have a slightly increased risk.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline strangerbynight

  • Member
  • Posts: 111
Re: What stage of liver damage for risk of cancer?
« Reply #2 on: July 28, 2017, 12:16:33 am »
Primarily F4 cirrhosis but I am guessing maybe F3 being near cirrhosis could have a slightly increased risk.
Thanks Lynn, i remember i saw an artical from one of the forum and someone said you can be at any stage to have a risk of hcc,

Offline Lynn K

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Re: What stage of liver damage for risk of cancer?
« Reply #3 on: July 28, 2017, 03:38:18 am »
I tend to doubt that.

What about F1 for example. I would think their risk is the same as anyone on the street the real risk is for those with cirrhosis where the risk is about 20% any given year. So if I have 4 friends with cirrhosis one of us will develop HCC in a year. This is assuming no cure of hep c. After cure HCC risk even for those like me with cirrhosis is diminished.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Gaj

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  • Posts: 172
  • Optimist
Re: What stage of liver damage for risk of cancer?
« Reply #4 on: July 28, 2017, 10:25:53 pm »
There has been a lot of discussion of HCC over the last year which has unfortunately caused concern for many with HCV who are not actually in the high risk group. Those with cirrhosis should be aware that it is the cirrhosis that is the main driver of HCC which is why it is important for those with high fibrosis levels (high F3 to F4) to continue regular annual or biannual checks including U/S or CT scans after SVR. However, for those with lower levels of fibrosis the risk is more in line with the general population and very low, but if you have concerns you should discuss these with your doctor or specialist. Here is some information on HCC in relation to causative disease from The Oncologist.

Quote
"The primary risk factor for developing HCC is cirrhosis, the major causes of which are HBV and HCV infection. Indeed, there is evidence to show that 50% of all cases of HCC worldwide are associated with HBV infection, with a further 25% associated with HCV [12]. The annual incidence rates of HCC in patients with cirrhosis according to individual underlying disease are shown in Table 1."

http://theoncologist.alphamedpress.org/content/15/suppl_4/14.full

And a link to Table 1 from above which shows the annual risk by causative disease.

http://theoncologist.alphamedpress.org/content/15/suppl_4/14/T1.large.jpg

Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline Lynn K

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Re: What stage of liver damage for risk of cancer?
« Reply #5 on: July 28, 2017, 11:58:36 pm »
I like the 1-8 % better than the 20% I had  previously heard.

Wish there was more data for people with cirrhosis who have  cured their hepatitis c what those odds are like
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline strangerbynight

  • Member
  • Posts: 111
Re: What stage of liver damage for risk of cancer?
« Reply #6 on: July 29, 2017, 12:52:45 am »
So then in my case i should good ? My fribroscan is 6.2 kpa with medium probe used so its rated on the chart F0-1, i heard that theres a link with DAA cuases hcc during and after treatment thats why i am very concern because i am starting my generics harvoni next week and also 4 months ago i got an ultralsound of my lever and they found 1 hemahemangioma and the second one they think its a small cyst, the treaments is near and my axiety flares up again and i am worry as hell.

Offline Lynn K

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  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: What stage of liver damage for risk of cancer?
« Reply #7 on: July 29, 2017, 12:58:16 am »
The link is unclear if it actually exists and in any event those who are related to this risk are those with cirrhosis who previously had liver cancer.

So this still unproven risk does not apply to you.

Cysts are generally benign  and hepatic hemangioma is a noncancerous tumor in the liver that's made up of a tangle of blood vessels. Liver hemangiomas typically don't cause symptoms or require any treatment. They're usually found during a test or procedure for a different condition.
« Last Edit: July 29, 2017, 01:02:31 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: What stage of liver damage for risk of cancer?
« Reply #8 on: August 24, 2017, 10:20:23 pm »
With or without cirrhosis our risk for liver cancer decreases by eliminating Hep C!
No cirrhosis and no Hep C = back to the same risk as the general population.

#gratitude
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

 


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