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Author Topic: Epclusa  (Read 8717 times)

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Offline JimA

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  • Posts: 8
Epclusa
« on: January 17, 2018, 07:19:54 pm »
I was under the impression that I was going to be treated using Harvoni and did a lot of research. Went to Dr. today and picked up my meds and I'm actually going to be using Epclusa (400mg sofosbuvir and 100mg velpatasvir). Any info on these well these meds work would be very helpful. Thanks in advance Jim
I'm Hepc type 2

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Epclusa
« Reply #1 on: January 18, 2018, 01:58:41 am »
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm508915.htm

"The safety and efficacy of Epclusa for 12 weeks was evaluated in three Phase III clinical trials of 1,558 subjects without cirrhosis or with compensated cirrhosis (mild cirrhosis). Results demonstrated that 95–99 percent of patients who received Epclusa had no virus detected in the blood 12 weeks after finishing treatment, suggesting the patients’ infections had been cured."

http://www.gilead.com/~/media/files/pdfs/medicines/liver-disease/epclusa/epclusa_pi.pdf

See table 10 page 31 and table 11 page 32 which show 100% and 99% SVR respectively for genotype 2

Are you aware of the copay coupon for Epclusa?

https://www.epclusa.com/co-pay-coupon-registration?utm_source=google&utm_medium=cpc&utm_campaign=624265620&utm_term=%2Bepclusa&utm_content=28839024654&gclid=EAIaIQobChMIhe6vyvbg2AIVx1t-Ch1JKAp-EAAYASABEgLCdvD_BwE&gclsrc=aw.ds

ELIGIBLE PATIENTS MAY PAY NO MORE THAN $5 PER CO-PAY FOR EPCLUSA
We believe that cost should not be a barrier to receiving treatment. That’s why the makers of EPCLUSA offer a co-pay coupon. If you are eligible, you may pay no more than $5 per co-pay. Need a replacement coupon?

Please note the following:

You are not eligible if you are enrolled in a government healthcare prescription drug program such as Medicare Part D or Medicaid. This includes when you are in the Medicare Part D coverage gap known as the “donut hole.”

The EPCLUSA Co-pay Coupon Program will cover the out-of-pocket costs of your EPCLUSA prescriptions up to a maximum of 25% of the catalog price of a 12-week regimen of EPCLUSA. See Terms and Conditions below.
« Last Edit: January 18, 2018, 02:01:11 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Epclusa
« Reply #2 on: January 18, 2018, 04:19:24 am »
Hi, Jim.

Harvoni and Epclusa each contain two medicines, one of which is sofosbuvir (brand name Sovaldi), approved by the FDA on 12/06/2013. They differ only in the second drug: ledispasvir in Harvoni; velpatasvir in Epclusa. For your genotype, Epclusa is better: https://www.hcvguidelines.org/treatment-naive/gt2/no-cirrhosis

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline JimA

  • Member
  • Posts: 8
Re: Epclusa
« Reply #3 on: January 18, 2018, 07:43:01 pm »
Thank you so much for the replies good information. No didn't know about the coupon that is great news my copay is kinda high so that would help. I have Kaiser wonder if that works with them. Guess I'll print it out and see what they say.Thank you very much for that link.
Jim
« Last Edit: January 18, 2018, 07:49:27 pm by JimA »

Offline JimA

  • Member
  • Posts: 8
Re: Epclusa
« Reply #4 on: January 27, 2018, 10:07:59 am »
Kaiser does not accept the coupon but I can get reimbursed. I'll post when I get all the information. I start taking my pills today.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Epclusa
« Reply #5 on: January 28, 2018, 02:19:28 am »
Bummer about Kaiser I wonder why :(

Good luck Jim!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline JimA

  • Member
  • Posts: 8
Re: Epclusa
« Reply #6 on: January 30, 2018, 03:13:09 pm »
I hope this helps anyone who has Kaiser insurance.

Ok here is the info to get reimbursed of EPCLUSA from Kaiser. Call EPCLUSA # 855-769-7284 talk to a case manager to have coupon activated and mailed to you. DO NOT pickup perscription from Kaiser until after you have called and activated coupon. When you pickup meds and have the 9x11 hard copy of the receipt from release of medical information from Kaiser call 866-566-6446. They will help you through the procedures to fill out forms and mail it in to them. Rebate takes 4 to 6 weeks. It isn't as bad as it sounds lol. At least you will be reimbursed yay. I am on day 4 of treatment and so far so good no side effects at all. Thanks to all that helped.. Jim
« Last Edit: January 30, 2018, 03:29:31 pm by JimA »

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Epclusa
« Reply #7 on: January 30, 2018, 09:30:42 pm »
Glad you worked it out and thanks for the info for those who come after :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline JimA

  • Member
  • Posts: 8
Re: Epclusa
« Reply #8 on: February 14, 2018, 05:32:42 pm »
Got results from blood tests, 4 weeks on meds. Viral load went from 5 million down to 600. It's a good start. I know the important test is the one 12 weeks after but trending in the right direction.

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Epclusa
« Reply #9 on: February 14, 2018, 07:31:18 pm »
JimA, glad you're well on your way to a cure.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

 


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