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Author Topic: Half way through, still detected  (Read 1149 times)

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Offline techguy

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  • Posts: 4
Half way through, still detected
« on: August 11, 2018, 12:23:36 am »
After four weeks of Mavyret, my doctor today said that the virus is still detected even though much lower load now (down to 60 from 11M) and liver shows normal readings for the first time in years.

She’s not telling me much more except more lab tests are coming and we’ll decide what to do after three months post treatment.

But if it’s still detected after 8-week treatment is over, what typically happens then? We try a different pill? Does insurance usually approve it? I had no issues with this first approval.

Not terribly worried yet, but also not the news I was hoping for so any insights from you all is appreciated.

Offline Lynn K

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  • Posts: 3,870
  • Get tested, get treated, get cured, fight Hep c!
Re: Half way through, still detected
« Reply #1 on: August 11, 2018, 01:57:32 am »
We had a couple of people here who were weakly detected at EOT (end of treatment) and even at 4 weeks post who went on to become not detected at 12 weeks post. On treatment testing means little it only really confirms you are taking your meds. While most people do become not detected early on in treatment not everyone does. You can look up dragonslayers posts to see his story.

The only test that counts is the 12 week post treatment test.

There have been a few here who did relapse myself included who were later retreated successfully. But just focus on your current treatment for now and tomorrow will take care of itself.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline andrew j

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  • Posts: 412
Re: Half way through, still detected
« Reply #2 on: August 11, 2018, 07:46:10 pm »
Hi techguy,

Quite a few people have a bit left at around 4 weeks.
I had 18 left at 5 weeks [of a 12 week Tx with Harvoni].

It's that huge drop they're looking for at 4 weeks - and that's most definitely you.
(... You know - 60 is a very different number to 11 million!).

If you had thousands, or even hundreds, left at this stage - there might be some cause for concern - but your liver readings [also] suggest that these meds are doing
their work!

8 weeks of Mavyret looks to be a very effective Tx.

Hoping to hear that you are cured, soon!

A.

Offline techguy

  • Member
  • Posts: 4
Re: Half way through, still detected
« Reply #3 on: August 13, 2018, 01:37:07 pm »
Great - thank you for chiming in. I'll wait and see.

Offline iraida1996

  • Member
  • Posts: 3
Re: Half way through, still detected
« Reply #4 on: August 14, 2018, 05:53:12 am »
Hi everyone, hope your treatment is going well.

I am genotype 1b and have been treated with Zepatier and the virus was undetected after 2 weeks of treatment but it relapsed 12 weeks post end of treatment. I am currently on 12 weeks of Sovaldi and the virus has decreased significantly.

I am concerned about sun exposure and long working hours and whether that would have an impact on the treatment and potentially prevent me from being successfully treated with Sovaldi.

Any help would be greatly appreciated and would put my mind at ease.

Thank you x

Offline Lynn K

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  • Posts: 3,870
  • Get tested, get treated, get cured, fight Hep c!
Re: Half way through, still detected
« Reply #5 on: August 14, 2018, 12:28:23 pm »
Per the prescribing information for Sovaldi

http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf

It is not a stand alone medicine. For genotype 1 Sovaldi should be taken “SOVALDI + peginterferon alfa + ribavirin 12 weeks”

This seems an odd choice for some one who failed on Zepatirer.

Are you seeing a doctor with experience in treating hep c?

Olysio is the medicine that had warnings about sun exposure.

I am guessing Epclusa might have been a better choice then Sovaldi and as I said Sovaldi alone is not a treatment recommended for any form of hep c
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline iraida1996

  • Member
  • Posts: 3
Re: Half way through, still detected
« Reply #6 on: August 14, 2018, 12:31:01 pm »
Thank you so much for your reply.

I have made a mistake, it is actually Vosevi I am on, I have been very tired and forgetful on Vosevi and made a silly mistake

Offline Lynn K

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  • Member
  • Posts: 3,870
  • Get tested, get treated, get cured, fight Hep c!
Re: Half way through, still detected
« Reply #7 on: August 14, 2018, 09:17:47 pm »
No worries we all make mistakes from time to time :)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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