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Author Topic: Have There Been Relapsers on Vosevi 12 weeks?  (Read 1223 times)

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Offline Lukey

  • Member
  • Posts: 315
  • Let Thy Food Be Thy Medicine
Have There Been Relapsers on Vosevi 12 weeks?
« on: January 07, 2019, 09:44:57 pm »
If so I have not heard of them.

I'm getting tested for SVR-16 soon and hoping for it.
I have no reason to think I relapsed but it will be nice of I can get that SVR16.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"
4 weeks post : "<15 not detected"

Offline KimInTheForest

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  • Believe in yourself
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #1 on: January 08, 2019, 12:53:05 am »
I'm sure you'll be 'undetected'. But it is always nice to see those words on paper! :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Lynn K

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  • Member
  • Posts: 4,079
  • Get tested, get treated, get cured, fight Hep c!
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #2 on: January 08, 2019, 03:05:05 am »
Haven’t seen any relapsed that I can recall. Have you had any post treatment testing?

I have read your odds of SVR if not detected at 4 weeks post are about 98.5%
« Last Edit: January 08, 2019, 03:12:31 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

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  • Posts: 315
  • Let Thy Food Be Thy Medicine
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #3 on: January 08, 2019, 05:41:14 pm »
Thank you both.   ;D

Lynn,

I got my SVR4 in late October.

Someone on another forum did 12 weeks Vosevi and was "mildly detected" at <12 at EOT. Didn't you say most people will go on to get SVR with this outcome?
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"
4 weeks post : "<15 not detected"

Offline Lynn K

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  • Member
  • Posts: 4,079
  • Get tested, get treated, get cured, fight Hep c!
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #4 on: January 08, 2019, 07:36:43 pm »
I am guessing I probably referenced dragonslayers story of being weakly detected at EOT and again at 4 weeks post but he went on to achieve SVR12 and remains cured.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline dragonslayer

  • Member
  • Posts: 868
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #5 on: January 08, 2019, 10:39:38 pm »
I am guessing I probably referenced dragonslayers story of being weakly detected at EOT and again at 4 weeks post but he went on to achieve SVR12 and remains cured.

Yay, Lynn  ;D   You have a good memory..   Glad I can be the one to prove, for those few that are still detected at EOT, it  aint no thing!!!
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Lynn K

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  • Posts: 4,079
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Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #6 on: January 08, 2019, 10:59:34 pm »
Yeah you are a cautionary tale lol ;)
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lukey

  • Member
  • Posts: 315
  • Let Thy Food Be Thy Medicine
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #7 on: January 08, 2019, 11:29:37 pm »
I seem to be SVR. I'm like a different man, even though it's taking a while to kick the Vosevi hangover.
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"
4 weeks post : "<15 not detected"

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,079
  • Get tested, get treated, get cured, fight Hep c!
Re: Have There Been Relapsers on Vosevi 12 weeks?
« Reply #8 on: January 08, 2019, 11:37:45 pm »
Did you get your 12 week post treatment results? Congrats!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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