Any updates on treatment for those who are co-infected?

[d-boy86]

I keep reading some post here which I find to be discouraging. However, this may be due to the fact of the information being out dated. Any luck with treatment updates for those who have both?

[iana5252]

The most recent treatment update is from March:
Incivek Improves Outcome and Halves Treatment Time for HCV in HIV-Positive Men
http://www.hepmag.com/articles/Incivek_HIV_2501_23658.shtml

The 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013) just wrapped up in Kuala Lumpur, Malaysia. I asked our editorial team if they had seen any new co-infection treatment updates and they said no. If anything pops up I'll post it here.

The next conference where news may be announced is the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) in September.

[d-boy86]

The most recent treatment update is from March:
Incivek Improves Outcome and Halves Treatment Time for HCV in HIV-Positive Men
http://www.hepmag.com/articles/Incivek_HIV_2501_23658.shtml

The 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013) just wrapped up in Kuala Lumpur, Malaysia. I asked our editorial team if they had seen any new co-infection treatment updates and they said no. If anything pops up I'll post it here.

The next conference where news may be announced is the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) in September.

Thanks! Any idea on when this will be available for use for those who are co-infected?

[fullof?]

Hi d-boy,

Have you seen the TAG pipeline report?
http://www.treatmentactiongroup.org/sites/tagone.drupalgardens.com/files/201306/2013%20Pipeline%20Report.pdf

It's got a ton of information on HCV treatment drug development. Jump to page 181 for the HCV/HIV information. Here's some of what they have to say...

HIV/HCV Coinfection
HCV coinfection increases AIDS-related, liver-related, and all-cause mortality among people with HIV, despite use of antiretroviral therapy (ART).37,38 The incidence of HCV-related complications has been rising sharply among HIV/HCVcoinfected people. Since 1996, the incidence of cirrhosis among HIV/HCV-coinfected patients in care at the Veteran’s Administration (VA) has risen from 3.5% to 13.2%, and hepatocellular carcinoma from 0.07% to 1.62%— a shocking 23-fold increase.

Clearly, people who are HIV/HCV-coinfected ought to be a priority population for DAA trials, since they are at risk for more rapid HCV progression. Sponsors stand to benefit from supporting these trials, since systems that deliver ART to HIVpositive people could be expanded to include DAAs for both HCV-coinfected and HCV-monoinfected people. But development of peginterferon-free trials has been lagging: as of May 2013, only one peginterferon-free trial (sofosbuvir and ribavirin) was open to HIV/HCV-coinfected people; ongoing trials with simeprevir, faldaprevir, and daclatasvir are peginterferon-based.

But there is welcome news: initial reports that HIV does not appear to be a prognostic factor when a DAA is added to peginterferon and ribavirin have been supported by data from trials of telaprevir-based treatment, as well as interim reports from STARTVerso 4 (faldaprevir-based treatment) and the TMC435-C212 (simeprevirbased treatment) study.

[d-boy86]

Hi d-boy,

Have you seen the TAG pipeline report?
http://www.treatmentactiongroup.org/sites/tagone.drupalgardens.com/files/201306/2013%20Pipeline%20Report.pdf

It's got a ton of information on HCV treatment drug development. Jump to page 181 for the HCV/HIV information. Here's some of what they have to say...

Thanks. None of this looks promising for those who are coinfected though, or am I reading it incorrectly?

[iana5252]

Here is some news out of the International AIDS Society (IAS) Conference in Kuala Lumpur. Unfortunately it isn't good.

Hep B or C Coinfection Spells Worse Response to HIV Meds
http://www.hepmag.com/articles/coinfection_treatment_2501_24270.shtml

People with HIV who are coinfected with either hepatitis B or C virus (HBV/HCV) experience diminished response to antiretroviral (ARV) treatment for HIV and have a greater risk of death when compared with those monoinfected with HIV.

[d-boy86]

I read that. However, I believe this is only for those who are just starting treatment. My HIV has been well controlled and undetectable for over 3 years. Even after testing positive for Hep C. So that I'm not worried about.

[iana5252]

Finally some good news...

Victrelis Ups Hep C Cure Rates in Those Coinfected With HIV
http://www.hepmag.com/articles/Victrelis_coinfected_2501_24273.shtml

Looks like it was just for folks new to treatment.

The investigators conducted a double-blind, randomized, controlled Phase II trial of 99 coinfected adults who had untreated genotype 1 of hep C and an undetectable HIV viral load.