HARVONI AND TYLENOL

[Alfredo]

Can harvoni and tylenol be taken together?

[Ruthie]

They sure can. Just be careful if you have cirrhosis.  And drink tons of water. 

[Lynn K]

Tylenol is actually the preferred pain reliever with cirrhosis as long as no more than 2000 mg / day This is because people with cirrhosis have increased bleeding risk so cant take aspirin Advil Aleve etc

[Alfredo]

Lynn, is that because of the varices ?

[Lynn K]

Here is some info

http://www.aafp.org/afp/2009/1215/p1371.html

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used, but have risks associated with their use, including significant upper gastrointestinal tract bleeding. Older persons, persons taking anticoagulants, and persons with a history of upper gastrointestinal tract bleeding associated with NSAIDs are at especially high risk. Although aspirin is cardioprotective, other NSAIDs can worsen congestive heart failure, can increase blood pressure, and are related to adverse cardiovascular events, such as myocardial infarction and ischemia. Cyclooxygenase-2 inhibitors have been associated with increased risk of myocardial infarction; however, the only cyclooxygenase-2 inhibitor still available in the United States, celecoxib, seems to be safer in this regard. Hepatic damage from NSAIDs is rare, but these medications should not be used in persons with cirrhotic liver diseases because bleeding problems and renal failure are more likely. Care should be used when prescribing NSAIDs in persons taking anticoagulants and in those with platelet dysfunction, as well as immediately before surgery.

[Lynn K]

Also

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861975/pdf/mayoclinproc_85_5_008.pdf

Pain Management in the Cirrhotic Patient:
The Clinical Challenge

[Alfredo]

Great article, thanks.