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Author Topic: Viekira Pak Cures 100% of Genotype 1b's  (Read 15191 times)

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Offline Hep Editors

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  • Posts: 784
    • Hep Mag
Viekira Pak Cures 100% of Genotype 1b's
« on: July 01, 2015, 01:06:15 pm »
AbbVie’s Viekira Pak (ombitasvir/paritaprevir/ritonavir; dasabuvir) cured all people with genotype 1b of hepatitis C virus and compensated cirrhosis in a recent late-stage trial. The phase IIIb TURQUOISE-III study gave 12 weeks of the therapy to 60 participants...

All were cured. The most commonly reported side effects were fatigue (22 percent), diarrhea (20 percent) and headache (18 percent).

For more info: http://www.hepmag.com/articles/Viekira_genotype_1b_2501_27463.shtml

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Offline Downnout

  • Member
  • Posts: 21
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #1 on: July 03, 2015, 09:51:15 pm »
Any one have price comparisons between all the different meds for HepC and by company?
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Offline CHepCFree

  • Member
  • Posts: 66
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #2 on: October 24, 2015, 12:56:14 am »
FDA has issued a warning on October 22. 

http://www.fda.gov/Drugs/DrugSafety/ucm468634.htm
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Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #3 on: October 24, 2015, 01:42:48 am »
Viekira Pak is contraindicated in patients with moderate and severe hepatic impairment (Child-Pugh Class B & C).
Technivie is not indicated for use in patients with cirrhosis, and should not be used in patients with moderate and severe hepatic impairment (Child-Pugh Class B & C).
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #4 on: October 25, 2015, 01:34:19 pm »
I am 1b so that makes me very very happy to hear.I do have one question that maybe someone can answer.At EOT how long does it take for the Viekira to leave your system?Thanks
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #5 on: October 25, 2015, 04:57:29 pm »
I'm sure someone will chime in that knows for sure.  I am assuming no riba?  Riba is the one that takes 4 or more weeks.  Harvoni I know takes about 3-4 days and is supposed to pass very quickly...which is one of the reasons they stress not to miss a dose or two.  as for Viekira alone I imagine similar to Harvoni since they are similar acting.  Let see what the smart people have to say  :)
Logged
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #6 on: October 26, 2015, 01:45:40 am »



Half‐Life:

Ombitasvir: 21‐25 hours; Paritaprevir: 5.5 hours; Ritonavir: 4 hours; Dasabuvir: 6 hours

https://en.m.wikipedia.org/wiki/Biological_half-life

The biological half-life or terminal half-life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity

In other words after a given time the amount of meds in the blood is reduced by half. After the next same amount of time the new amount is reduced by half or 75% of the starting value. Again after the same time increment the new remaining total of 25% of the starting amount is reduced by half leaving 12.5% remaining and having reduced from the starting amount by 87.5% of the initial value

And so on .....

Hope that helps
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #7 on: October 26, 2015, 09:41:32 am »
I understand the half life Lynn.I worked as a lab animal technician with research animals for Florida State University so I'm good with all of that.I just don't know what the half life of Viekira is. :)
« Last Edit: October 26, 2015, 09:46:18 am by BillT »
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #8 on: October 26, 2015, 11:39:29 am »
Bill, now that Lynn has told you the half life of each of the four drugs that together are called Viekira, I presume Ombitasvir, the longest at 21-25 hours, would be key to the answer. After a week, there'd be less than 1% left (and smaller amounts of the other three components of Viekira).  -Gnatty
Logged
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #9 on: October 26, 2015, 12:18:51 pm »
Thanks Lynn and Gnatty,

                                  I need to stop thinking of this as a one drug treatment which is what I have been doing.I have a bit of brain fog right now so I'm not 100% in my thinking.This was more for information sake and doesn't really mean anything in the big picture.Thanks again to both of you.


             Knowing your dragon will help you win.
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #10 on: October 27, 2015, 12:06:52 am »
OK didn't know you background not every one here is a lab technician

Or even a rocket scientist lol ;)

Also, others who read later might need the extra definition of half life.
« Last Edit: October 27, 2015, 12:09:02 am by Lynn K »
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #11 on: October 27, 2015, 05:28:48 pm »
Hi Lynn,

           I actually live in Titusville Florida about 8 miles from the space center.I know a few rocket scientists and us lab animal technicians are much more intelligent.  :)
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #12 on: October 28, 2015, 02:38:08 am »
Hi Bill

My folks retired to Florida when I was still in high school. I finished high school near Ocala actually Lake Weir if you know the area at all.

Now I work for a large aerospace company in the pacific NW we have lots of Aeronautical engineers here if it ain't broke they will break it so they can design a fix :)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #13 on: October 29, 2015, 05:54:25 pm »
Hi Lynn,

           I love Ocala.I think it's the horse farms and the forests up there.I'm going to have to borrow your ASE comment if I can.I've got some friends that won't be ready for that one.LOL
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #14 on: October 29, 2015, 06:46:15 pm »
Quote from: BillT on October 29, 2015, 05:54:25 pm
Hi Lynn,

           I love Ocala.I think it's the horse farms and the forests up there.I'm going to have to borrow your ASE comment if I can.I've got some friends that won't be ready for that one.LOL

No problemo borrow away!  ;)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Viekira Pak Cures 100% of Genotype 1b's
« Reply #15 on: October 29, 2015, 08:26:23 pm »
By the way Lynn,I just noticed your undetectable status.I'm so very happy for you.Congratulations. :)
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)
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