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Author Topic: COBAS® TaqMan® TEST  (Read 4442 times)

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Offline jakas

  • Member
  • Posts: 265
COBAS® TaqMan® TEST
« on: March 04, 2016, 04:49:33 am »
This is the test I went for the VL AFTER END OF TREATMENT  am I right to assume that the lowest detection is 25 IU/mL ??

COBAS® TaqMan® HCV Test

Hepatitis C virus (HCV) viral load testing quantification
An in vitro nucleic acid amplification test for the quantitation of HCV RNA genotypes 1 through 6 in human serum or plasma.
 
The High Pure System Viral Nucleic Acid Kit allows manual specimen preparation and the COBAS® TaqMan® 48 Analyzer automates amplification and detection. This test utilizes realtime PCR technology for the detection and quantitation of HCV RNA.

Features and Benefits
 
Features
CE-IVD: Sensitivity (LOD; genotype 1) –  plasma: 9.3 HCV RNA IU/mL, serum: 8.8 HCV RNA IU/mL; linear range –  25 to 3.91×10^8 IU/mL

FDA-IVD: Sensitivity (LoD; across all genotypes) – 20 IU/mL; Linear range –Quantitation of HCV RNA from 25 to 3×10^8 IU/mL
COBAS® TaqMan® 48 Analyzer for automated real-time PCR amplification and detection

Benefits
Minimizes testing errors and manual intervention steps with automated closed-tube amplification and detection on the COBAS® TaqMan® 48 Analyzer
Improves result integrity with bar coded samples for sample tracking – AmpErase enzyme reduces risk of contamination – internal quantitation standard eliminates need for calibration
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: COBAS® TaqMan® TEST
« Reply #1 on: March 04, 2016, 04:46:22 pm »
You are correct
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

 


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