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Author Topic: Newer once daily pills deemed safer than harvoni.  (Read 7879 times)

0 Members and 1 Guest are viewing this topic.

Offline JackN

  • Member
  • Posts: 52
Newer once daily pills deemed safer than harvoni.
« on: April 18, 2016, 10:27:19 pm »
Hi all

Ran up on An [medical news today] article (you may need to google medical news today for hep c). It's  a newer, better safer drug is out.
1A
Likely infected 1970's
VL 575,000
Liver Functions normal (ALT/AST)
F0 Fibroscan
Started Harvoni 12-5-15
4week labs 63 VL
6week labs 21 VL
2-17-16 NONDETECTED :) prior to 12 week EOT
3-28-16 EOT 4 week testing = nondetected
5-11-16 EOT 10 week testing = nondetected

Offline JackN

  • Member
  • Posts: 52
1A
Likely infected 1970's
VL 575,000
Liver Functions normal (ALT/AST)
F0 Fibroscan
Started Harvoni 12-5-15
4week labs 63 VL
6week labs 21 VL
2-17-16 NONDETECTED :) prior to 12 week EOT
3-28-16 EOT 4 week testing = nondetected
5-11-16 EOT 10 week testing = nondetected

Offline Coach Mike

  • Member
  • Posts: 292
    • Affordable Hepatitis C Treatment
Re: Newer once daily pills deemed safer than harvoni.
« Reply #2 on: April 19, 2016, 05:18:39 am »
Hi,
Let's see what they price it at. It appears to be about as effective as Harvoni.
Far more effective than the old sofosbuvir combos.
cm
Genotype 1a, Biopsy:11/2014: F-1, Tx Naive
Fibrosure, 7/20/15: F-1-2
Pre tx v/l: 1,600,000, ALT: 75, AST: 48
Started generic sofosbuvir & ledipasvir: 10/23/15
4 wk labs: 11/19/15, ALT: 21, AST: 16, V/L:  UND
Started 8 week Harvoni tx: 11/20/15
8 wk labs, 12/15/15, ALT: 15, AST: 13, V/L: UND
4/11/16 12 week EOT-Undetected
7/5/16 SVR 24

Offline malou

  • Member
  • Posts: 57
Re: Newer once daily pills deemed safer than harvoni.
« Reply #3 on: April 19, 2016, 11:15:19 am »
This study compares the efficacy of Sofosibur/Interferon/Ribavirin compared to  Zepatier.  I would actually like to see a study comparing Harvoni (ledipasvir/sofosbuvir) to the Zepatier.  Certainly, Harvoni alone has much fewer side effects when not combined with Pegylated Interferon and Ribavirin, the latter two are responsible for the majority of side effects and adverse effects in all of the previous HCV treatments.  ML

HCV 1996- Work Exposure ER nurse
GT 1a
Non-responder to Interferon in 1997
ALT 73 AST 21 F1-2
Applied to Insurance for Harvoni 12-15
Denied 12-3-15  Told I would never qualify for Harvoni because I was not 'ill'.
Started Twinvir (Bengladesh Harvoni) on 1/1/16

After 4 weeks ALT 23, AST 15, HCV-RNA UNDETECTED
After 8 weeks:AST 23, AST 11, HCV RNA UNDETECTED
6 weeks post treatment, undetected.

Offline mamamia888

  • Member
  • Posts: 24
Re: Newer once daily pills deemed safer than harvoni.
« Reply #4 on: May 15, 2016, 10:51:45 am »
   After being denied from our insurance company for Harvoni, my husband has now been approved Zepatier for his treatment. He had to take a resistance test to determine if he will need a 12 or 16 week treatment.( Still waiting for results) He is hopeful he will not have to take Ribavirin along with the Zepetier.

   Just wondering if anyone has completed or are currently taking this medication?
genotype 1a
 started V-pak and riba on January 20,2016
 12 wk treatment plan
 VL-2,237,690
  Ferritin is elevated. Iron saturation and other liver       studies are normal
EOR _UNDECTABLE 7-22-16






























VL_15   2/22/2016
week 10- VL is UNDECTABLE

 


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