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Author Topic: The Liver Meeting 2016  (Read 9687 times)

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Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
The Liver Meeting 2016
« on: September 09, 2016, 12:51:51 am »
The AASLD's Liver Meeting will be held in Boston this year from Nov. 11 - 15th. I am sure there will be a LOT of new information this year!!  It's really been a stellar year for new treatment options, and such a big graduating class! FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline elias

  • Member
  • Posts: 285
Re: The Liver Meeting 2016
« Reply #1 on: November 13, 2016, 01:33:05 pm »
Anyone have links for developments at this important AASLD Meeting?

Would be good to keep updated
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline elias

  • Member
  • Posts: 285
Re: The Liver Meeting 2016
« Reply #2 on: November 14, 2016, 05:40:15 pm »
ooops!!! sorry

Lucinda Porter is keeping us informed, as usual:

https://www.hepmag.com/blog/highlights-2016-liver-meeting

Thanks Lucinda!!

-elias
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: The Liver Meeting 2016
« Reply #3 on: November 15, 2016, 08:46:14 pm »
Hi Lucinda

Did you see anything of interest for those of us with long standing cirrhosis as far as odds of liver improvement, regression of cirrhosis, or our prognosis in general?

Thanks
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Pete

  • Member
  • Posts: 110
Re: The Liver Meeting 2016
« Reply #4 on: November 16, 2016, 11:24:47 pm »
Small world, I got a note from my Hepatologist just yesterday who is at the Liver Conference in Boston this week.  She mentioned that she's learning about new treatments coming soon for those of us who fail DAA's.  She reassured me by stating that while she believes what I'm doing now (VP/Riba) will work, don't despair because "I will get you cured if it don't..."  Talk about uplifting!  It felt really good to know she took time out of her busy conference schedule send my positive vibes like that. 

I have an awesome doctor and proud to say so!   

Pete

Offline elias

  • Member
  • Posts: 285
Re: The Liver Meeting 2016
« Reply #5 on: November 17, 2016, 05:16:10 pm »
Lynn wrote:
Quote
Did you see anything of interest for those of us with long standing cirrhosis as far as odds of liver improvement, regression of cirrhosis, or our prognosis in general?

I too am very interested in this. As well as in fibrosis/cirrhosis regression in general.

Wondering if there are things we can actually do to improve odds and degree of such regression after HCV clearance? Not sure this meeting will address that

I already see some report on regression at the meeting. There will probably be more.
Would love to keep updated:

http://hepatitisc.hcvadvocate.org/2016/11/direct-acting-anti-viral-daa-therapy-chronic-hepatitis-c-virus-hcv-infection-associated-regression-liver-fibrosis-assessed-serial-transient-elastography-fibroscan.html
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: The Liver Meeting 2016
« Reply #6 on: November 17, 2016, 09:09:04 pm »
What we can do is if we are overweight or obese per our BMI scores is to lose weight as being overweight can contributate to having a fatty liver which will also cause liver problems all by itself.

Also I have read a heart smart diet is a liver friendly diet as well. Really no different than everyone should do maintain normal weight eat health and exercise. I need to do all of those things but easy to say harder to do
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline elias

  • Member
  • Posts: 285
Re: The Liver Meeting 2016
« Reply #7 on: November 17, 2016, 10:15:07 pm »
Ty Lynn:

That does simplify it some.

Is "heart smart diet" similar to one for insulin resistance or pre-diabetes?

Oddly enough. I had started such a diet and exercise program a few weeks before my HCV diagnosis.  Still not sure which of the several approaches for this was optimal. Coincidentally, I discovered i was suddenly in pre-diabetic fasting glucose range at same time my family doc noticed spike in my liver enzymes which led him to test me for HCV.

It's interesting, that I came across reference to relationship between insulin resistance and clearing HCV just today:

Quote


Abstract # 912 Impact of Sustained Virological Response to Direct Acting Antivirals on Insulin Resistance in Patients with Chronic HCV - Mostafa G. Elhelbawy, et al.

From:
https://www.hepmag.com/blog/effects-hepatitis-c-treatment-liver-meeting
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: The Liver Meeting 2016
« Reply #8 on: November 18, 2016, 01:25:59 am »
I was thinking the heart smart diet from the American Heart Association good general purpose information here is a link

http://www.heart.org/HEARTORG/HealthyLiving/HealthyEating/Healthy-Eating_UCM_001188_SubHomePage.jsp#mainContent

Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline elias

  • Member
  • Posts: 285
Re: The Liver Meeting 2016
« Reply #9 on: November 18, 2016, 05:03:45 pm »
The relationship between fibrosis/cirrhosis regression and insulin resistance is fascinating to me.

On the one hand, insulin resistance improves much after HCV is cleared. Conversely, diabetes decreases odds of such regression. Diabetes (adult onset) is later stage of insulin resistance. This is best viewed as a continuum.

About one quarter to third of Americans are believed have some form of insulin resistance or other. Increases with age. Most don't know it, and the definition and cutoffs for this change from year to year. It's actually defined arbitrarily , in terms  of cutoff glucose values used. It is quite treatable by diet, weight loss,  exercise, stress reduction, etc.

This bi-directional relationship between HCV and insulin resistance is something I'd like to learn more about
« Last Edit: November 18, 2016, 07:05:15 pm by elias »
Contracted HCV ~age 12
Diagnosed: September 2016 GT2b
F3 by Fibrosure: 0.66
Necroinflammat activity: A3 0.76
================
VL Sep. 12, 2016: 1.44 million/ Log: 6.157
AST:71/ ALT:114   Sept. 1, 2016 Before treatment
==================
4 week after beginning  Epclusa:
Viral Load: UNDETECTED
AST 17/ALT 11
===============
Began Epclusa:  October 22, 2016
End of Treatment [EOT]: January 13. 2017
====================
EOT+4 Weeks: UNDETECTED
====================
SVR 12 April14-HCV Not Detected

 


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