Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE! (Read 755916 times)

Ledoc01 · « **Reply #500 on:** August 13, 2015, 06:12:07 pm »

Well I had my 12 week post Tx VL draw 3 days ago. Driving down the road today I got a call from the Doc; I'm cured!!

I don't have any of the numbers from any tests yet but I *can* mention I was still detected at 4 weeks. I'll post more later.

Meanwhile...The Dragon can go suck eggs

KimInTheForest · « **Reply #501 on:** August 13, 2015, 06:21:39 pm »

CONGRATS LeDoc!!

kim

Ledoc01 · « **Reply #502 on:** August 14, 2015, 03:01:21 am »

Thanks Kim. I'm pleased to say the least. It hasn't fully sunk in yet. At this point I am cautiously optimistic though my gut tells me all is well. I still have cirrhosis (no exact numbers, I'm told it's on the real low end and, my tests have all been rock steady for the past few years. I'll continue having ultrasounds alternating with CT scans to monitor that. I also plan on having a 48 week VL done. I know the current thinking is if you're cool at 12 weeks then that's it however...it's my life and my money; I'll have the test.

Best of luck to you as well.

-d

Katie · « **Reply #503 on:** August 14, 2015, 03:25:19 am »

Congratulations Ledoc! The feeling takes awhile to settle in and then one day you realize, you're lighter feeling and less stressed and that you are no longer a biohazard and it's then you can truly celebrate! Have a wonderful life!

Katie

Downnout · « **Reply #504 on:** August 15, 2015, 04:51:54 pm »

Post 5 weeks of taking Sofosbuvir (generic) and Ribivirin Have some questions on blood test. Didn't see any liver readings but I'm concerned about the following
Test said <15 and not detected but what I'm concerned about is since I've had a liver transplant and on immune suppressants along with the above meds:

Hematocrit 29.7 LOW
Hemoglobin 9.8
carbon dioxide 21 low
creatinine 1.5 high
glomerular filtration rate 47 low
phosphate 2.4 low
Feel like CRAP = Extremely High
If I get in the sun and walk any amount my muscles go to mush and my heart pounds until I get inside in the cool and rest for about 5 minutes.
Blood pressure has been high - having to take around twice the normal dose.

Otherwise..LOL.. I feel great!

Lynn K · « **Reply #505 on:** August 15, 2015, 09:06:49 pm »

I would talk to your doctor but it does sound at least partly from Ribavirin caused anemia which is causing the low hemoglobin and anemia does tend to make on feel like crap.

Being post transplant I assume you're being closely monitored by your transplant physician while you are on treatment for hepatitis C with Sovaldi and Ribavirin.

I was on Harvoni 24 weeks and Riba for 15 weeks I was on 1200 mg Ribavirin but had to dose reduce because my HGB had dropped to 9.7 and my doctor did not want to see that below 10. After reducing to 1000 mg my HGB rose to 10.1

Congrats on the not detected good luck on treatment may you make SVR forever
Lynn

SIXFOOTFOUR · « **Reply #506 on:** August 17, 2015, 03:16:46 pm »

Got my 11 week EOT results back (mistake in test date and did it 1 week early) but they are thesame as my previous 6 week and 10 week during treatment results:

HCV RNA, <15 NOT DETECTED Range <15 = Normal
QUANTITATIVE IU/ml
REAL TIME PCR

HCV RNA, <1.18 NOT DETECTED Range <1.18 = Normal
QUANTITATIVE Log IU/mll
REAL TIME PCR

So I guess Im SVR 11

due to the date mistake. My doctor will have me come back for a 6 and 12 month test instead of repeating again in a week.

All other info is in my signature.

Thanks to all on this forum, you have been a great source of information and support.

I can say that my experience on treatment was very easy, only some headaches but increasing water and some Tylenol took care of that.

My side effects since completing tx have been much harder, a few days after completing my 12 weeks I started GI problems , off and on feeling more tired and weak. The side effects seem to be slowly getting better as its not almost every day now but Im 11 weeks EOT.

When I was on Harvoni I felt the best Ive felt in years, energy, appetite .

Katie · « **Reply #507 on:** August 17, 2015, 06:06:33 pm »

Me too Sixfooter! I still am not feeling up to par and I am 24 weeks post tx.. I suggest you report your after treatment side effect to Gilead as the more info they have, the better. I asked a question online and they called both me and my doctor, so evidently they are interested.

Congratulations on your success and I hope we all get our energy back so we can enjoy being HepC FREE....at last!

Katie

Mugwump · « **Reply #508 on:** August 17, 2015, 11:16:33 pm »

I am SVR 12

Working on a happy dance. The results came in early.

SO

Initial VL was 3 million

F4 cirrhosis

Treatment experienced

24 weeks tx

UND at EOT

UND at 12+ weeks EOT

Katie · « **Reply #509 on:** August 17, 2015, 11:43:54 pm »

HIP HIP HOORRRAY! WONDERFUL NEW ON YOUR SVR12! I HAVE MY DANCING SHOES ON FOR YOU!

Congratulations and best to you!

Katie

Lynn K · « **Reply #510 on:** August 18, 2015, 02:00:29 am »

Awesome news Mugwump super congratulations to youuuuuuuu

Another one bites the dust!

Mike · « **Reply #511 on:** August 18, 2015, 02:10:35 am »

Congrats Mugwump,

The long Hep-C highway has come to an end!

Best wishes on your new life! Mike

Philadelphia · « **Reply #512 on:** August 18, 2015, 08:40:59 am »

Mugwump - so happy for you!

slats1056 · « **Reply #513 on:** August 18, 2015, 10:49:47 pm »

Mugwump , Chalk another one up for the good guys!!!!!Congrats. I think my personal text reflects My feelings to You & others who persevered.

Bree · « **Reply #514 on:** August 18, 2015, 11:36:16 pm »

Yea Mugwump! I say Do the Dance!!! I hope to join this club by the end of the year!

KimInTheForest · « **Reply #515 on:** August 19, 2015, 01:06:06 am »

Spectacular news, Mugwump. Party on!

kim

mdj · « **Reply #516 on:** August 19, 2015, 08:05:38 am »

1. 4wk EOT VL: Undetectected
2. 8wk EOT VL: Undetectected
3. Treatment duration-12 weeks
4. tx naive
5. Genotype 1a
6. fibrosis status--F3-F4 (Mar 2015)
7. Initial VL (2.1million/Oct 2014; retest 700,000/March 2015)

Will provide 12 wk results in September.

slats1056 · « **Reply #517 on:** August 19, 2015, 08:33:39 am »

More good news MDJ. Before long the whole hep world will be shaking from all the HAPPY DANCES! I've got seven more weeks of Tx. left , staying the course.
Yippee Ki Yay Ya'll!!!

opaleye · « **Reply #518 on:** August 21, 2015, 01:59:50 pm »

1. 4 wk EOT VL: not tested
2. 15 wk EOT VL: ~ 170,000
3. Treatment duration-8 weeks
4. tx naive
5. Genotype 1a
6. fibrosis status--FibroSure F1-2 A2 (Oct 2014)
7. Initial VL 2,812,380 (Oct 2014)

Mugwump · « **Reply #519 on:** August 21, 2015, 03:42:22 pm »

@opaleye
I am so sad seeing this result. Perhaps the 8 week option needs to be dropped completely it seems that many of the treatment failures are either those who only had the 8 week option, or were borderline in need of 24 weeks but only took 12.

I see you were tx naive. So this is doubly concerning. To date Harvoni was our best shot without a doubt, here is hoping you can get on another tx plan soon. Your level of damage mirrors the level I had before my first treatment failure after tx in 2003- 2004.

Whatever happens please do not despair! It took over ten years for my liver to progress to F4 and even then I could still row my pontoon boat and cast a fly line.

I will not change my avatar to the dead dragon until I reach 24 weeks post tx undetected status, but regardless of how this works out for me I refuse to fall into a funk again in life because of HCV infection!

Keep up the fight and be kind to yourself it makes it easier to be kind to others.

Sincerely
Eric

opaleye · « **Reply #520 on:** August 21, 2015, 09:51:27 pm »

Thanks for the encouragement, Eric.

I am an eternal optimist and kept saying "I believe I'm cured until they tell me otherwise." Well, they told me otherwise today and I must admit it hit me pretty hard. Maybe not completely devastated but extremely disappointed for sure. I am allowing myself a day to mourn the death of Harvoni Hope, but tomorrow I will look ever outward and upwards to the Next Hope.

With you completing a 24 week treatment and being SVR at week 12, it shouldn't be long before you transform your avatar into the slayed dragon!

Take care,
~opaleye

mario555 · « **Reply #521 on:** August 22, 2015, 07:25:16 am »

After waiting for 5 weeks for my 12 weeks EOT results, I finally got them yesterday :
I am EOT 12 - UND and my doctor calls it cured! Hard to believe after almost 45 years with the disease!
16 week after a 24 weeks treatment I still have sides with bouts of tinnitus and dizziness and more trouble undertaking complex work so I guess this is it for accounting... I just turned 60 so I'll try to enjoy my retirement. My wife knew I was cured because of me undertaking lots of house projects and by my level of stamina. For me, I'll cautiously wait for my 24 weeks before being convinced!
Best of luck for everyone and my best advice is to take as much medication as financially feasible. Don't let insurance clerks decide on your length of treatment.

gnatcatcher · « **Reply #522 on:** August 22, 2015, 07:53:24 am »

Big Time CONGRATULATIONS, Mario! You were one of the people whose posts I eagerly looked forward to when the "Harvoni Side effects" thread was helping me decide whether to risk trying Harvoni. Sorry about the lingering sides -- may they not prevent you from having a wonderful retirement. -Gnatty

concerned father · « **Reply #523 on:** August 22, 2015, 10:01:33 am »

Congrats Mario. My daughter is starting her treatment in 8 days and I hope she will have success like you.

Lynn K · « **Reply #524 on:** August 22, 2015, 01:20:40 pm »

Marioooooooooo!!!!!!!

That is great fantastic wonderful news treatment bro!

We started this road a week apart so HAPPY for you you made it through!

All my best to you young man just reborn!

In health
Lynn

Imbb · « **Reply #525 on:** August 22, 2015, 01:31:20 pm »

Opaleye,

I am new to this forum and still finding my way about. So sorry to hear such rough news, what a disappointment it must be. I was trying to find if you ever had an undetected result, with viral load <15 and Not Detected on the report?

Appreciate your perspective towards the Next Hope. I join you in hoping it will lead to SVR.

Barbara

Mugwump · « **Reply #526 on:** August 22, 2015, 02:46:03 pm »

Quote from: mario555 on August 22, 2015, 07:25:16 am

After waiting for 5 weeks for my 12 weeks EOT results, I finally got them yesterday :
I am EOT 12 - UND and my doctor calls it cured! Hard to believe after almost 45 years with the disease!
16 week after a 24 weeks treatment I still have sides with bouts of tinnitus and dizziness and more trouble undertaking complex work so I guess this is it for accounting... I just turned 60 so I'll try to enjoy my retirement. My wife knew I was cured because of me undertaking lots of house projects and by my level of stamina. For me, I'll cautiously wait for my 24 weeks before being convinced!
Best of luck for everyone and my best advice is to take as much medication as financially feasible. Don't let insurance clerks decide on your length of treatment.

RIGHT ON. I too still have the minor side effects you are experiencing. But I think that is because our livers needed to remove far more dead material than those people who have less liver damage. My bilirubin count is still up but here is hoping that I still have enough function left to bring the count down slowly over time as the damage levels off. We cannot forget that we have liver damage but it is certainly FANTASTIC to know that any more damage that occurs will not be from HCV.

Take good care and all the best to you.

Eric

PS I am starting a new thread for 24 week EOT test so that this thread can stay for those who reach 12, I feel that the 24 week clear or not EOT tests need to be documented as well. Like you Mario I know that I will not start to feel that things are over until November!

gnatcatcher · « **Reply #527 on:** August 22, 2015, 03:37:49 pm »

Mugwump/Eric, belated congratulations on your SVR12. You were another of the people whose posts I eagerly looked forward to while I was a lurker contemplating treatment. I'm so glad you have your music-making back and you continue to share your wit and encouragement with the rest of us.

Gnatty (a former musician who loves to photograph our fellow fauna, fish included)

Phil · « **Reply #528 on:** August 24, 2015, 02:11:50 am »

Today I received the results of my testing at 12 weeks post treatment with Harvoni.
Results: HCV RNA by PCR: Not Detected.

Meaning I have achieved End of Treatment Sustained Viralogic Response at 12 weeks.
EOT SVR at 12wk

Those test results from 08/12/2015:

HCV RNA by PCR
< 15 Not Detected IU/ml
< 1.18 Not Detected Log IU/ml

~ALT 68 Normal: Reference Range 12-78
^AST 59 Mildly Elevated: Reference Range 15-37

1. Testing done at 12 wk EOT

2. Treatment was with Harvoni for 12 Weeks. 02/19/2015-05/13/2015

3. Status before treatment: Treatment naive

4. Genotype 1a

5. F2 fibrosis by liver biopsy 2008.
F4 fibrosis by FibroSURE 2015. FibroSURE is of questionable accuracy, in my opinion.

6. Initial Viral Load was only 11,256, on 01/2015. Prior viral loads where also low, in the 20,000 range.

Phil

I should add that I am 61 years of age. I likely got Hepatitis C from an occupational needle stick injury in 1987. I was diagnosed in 2008. I have experienced extra hepatic manifestations of hep c, including avascular necrosis of both hips and both shoulders, requiring a left total hip replacement and a free fibular graft on the right, and pressure directed decompressives surgeries of both shoulders. Today most people have no idea I ever had those problems/surgeries. In addition I had a pulmonary embolism, not related to the surgeries, and ARDS, which damn near killed me. I was two weeks in the ICU with a breathing tube, on a respirator. All of these problems have an inflammatory and vascular occlusive origin in general and in my case were clearly caused by hep c infection. The association between hep c, avascular necrosis, pe, and ARDS can also be seen in the medical literature, but you have to dig deep. Although the general medical community is still playing catch up, this association is much better understood than when I first started looking 12 years ago. This is common for the progression of such medical knowledge. In my case the association is as statistically certain as that my DNA is my DNA. And I don't have a twin. A young healthy person (I was 48) with no medical history can simply not get three major illnesses within a short time which do not have a unifying cause. Not going to happen. More likely to find a case of in person voter fraud in the United States of America, or get struck by lightening, 5 times.

I was out of work, on total disability, for over two years. Today I'm back to work full time. The experience was actually helpful for me professionally, although I wouldn't recommend it on that basis alone.

Phil · « **Reply #529 on:** August 24, 2015, 04:20:33 am »

Quote from: JoeK9999 on July 13, 2015, 07:59:58 pm

It worked!!!!! I feel great. It took about 5 months after EOT on Harvoni before
side affects wore off. (dizziness mainly).

Congratulations Joe!

It is my opinion however, that we should stop thinking about the prolonged recovery time after a cure with Harvoni as "side effects" and start thinking of it as what is is. Recovery. So you had a virus, you took a medication, that medication killed the virus. Now your body has to recover. From the long term effects of the virus and the short term effects of medication. It's not like taking penicillin for a strep throat, slam bam thank you penicillin. Many of us have had hep c for 20-40 years. So long that many of us have forgotten what normal felt like. The hep c virus causes a lot of havoc over that time. It's not at all surprising the recovery is prolonged. I would guess 6 months to a year, perhaps longer depending on the chronic effects of the virus on an individual. Maybe 2 years for some. We don't know. The human race has never before experienced mass cure and recovery from a prolonged chronic viral infection. Never happened before. New territory. But it's not side effects necessarially. Side effects occur while taking a medication. Once the medication has cleared the system that's done. Gone. Even if the side effects persist. Now if a medication causes damage to some body system, well that's one more injury involved in recovery. Even if initially an effect of the medication. My point is some folks, not picking on you Joe just sayin', want to attribute every not so great thing they feel to Harvoni, neglecting the illness and recovery, which in and of itself is plenty to cause you to feel like crap for a good while. I'm not saying Harvoni has no significant side effects. I'm sure it does. It's a pretty damn powerful chemical. However no matter what, most of us are not going to feel recovered just because we are cured. Recovery takes time.

I myself at 14 weeks post Harvoni, with a SVR12, have just this week felt I have turned the corner in that process of recovery.

Phil

Mugwump · « **Reply #530 on:** August 24, 2015, 04:21:37 am »

Right on PHIL!

I think we should all see if we can get new scans done next year to see if the density status of our livers changes at all. I am sure that the GI's will be studying the results on the liver of those who have had the miracle cure just in time.

I firmly remember how having a status greater than F2 greatly reduced the possibility of success with Interferon tx! So no doubt how well our livers actually heal after successful Harvoni tx should make a very interesting item for clinical study to say the least.

Best wishes in what ever you do going forward!
Eric

gnatcatcher · « **Reply #531 on:** August 24, 2015, 06:33:08 am »

Phil, congratulations on your SVR. Thank you for your cogent exposition of the distinction between side effects and recovery.

Gnatty

coloradogirl · « **Reply #532 on:** August 24, 2015, 11:36:26 am »

Good news and bad news.
Bad news: The stock market fell 1000 points this morning.
Good news: SVR12!!!

Keeping it in perspective daily = Life is good!

mario555 · « **Reply #533 on:** August 24, 2015, 11:48:21 am »

Colorado girl congrats for your SVR!! I just received the same news Friday and I am just starting to process the first few days of my new life! Haven't figured it well yet...
As for the bad wake up news about the market it's a hidden gem! Gilead is down to 100 and is worth 120+. Buy, buy, buy....
In any case, I'm happy for you and good luck!

coloradogirl · « **Reply #534 on:** August 24, 2015, 02:07:07 pm »

Quote from: mario555 on August 24, 2015, 11:48:21 am

Colorado girl congrats for your SVR!! I just received the same news Friday and I am just starting to process the first few days of my new life! Haven't figured it well yet...
As for the bad wake up news about the market it's a hidden gem! Gilead is down to 100 and is worth 120+. Buy, buy, buy....
In any case, I'm happy for you and good luck!

I am so happy for YOU too, Mario! I understand how you feel about the first few days of your new life. I don't know what I want to do when I grow up, either. ;-)

I hope we see more of you all reporting an SVR12, too. Want to take you all with me!

Phil · « **Reply #535 on:** August 24, 2015, 06:12:33 pm »

Doesn't seem real does it? After so many years. I mean the SVR. The stock market is all about China's troubles. Life's a tricky business all around.

Congratulations to all the new and old cures. Understanding and dealing with recovery is the next challenge for those with SVR. The medical community by nature will not have any particular interest in this part. Nothing to fix. Folks here sharing and documenting the experience will be useful information. Hope everyone is doing well.

Phil

TTSP · « **Reply #536 on:** August 24, 2015, 06:16:34 pm »

SVR12 undetected.
1b
everything normal
except of course F4 (did not expect any change here)
treatment naive

Still having ringing in ear (singular because my other one has never worked since early childhood)
I was diagnosed with Menier's long ago.

Other than that I feel great!

Best wishes to all.

coloradogirl · « **Reply #537 on:** August 24, 2015, 08:01:22 pm »

Congratulations, Phil! Even though the market went south, I'm smiling and content.

mario555 · « **Reply #538 on:** August 24, 2015, 08:31:40 pm »

Congrats TTSP. May you live long and prosper!

Must have been hell to be deaf in one ear and have tinnitus in the other! Although it's been coming down, I still have tinnitus in one ear 2-3 times a week (scale 4 compared to 8 during treatment) even after 17 weeks post treatment. I prefer to deal with this rather than hep c.....

Phil · « **Reply #539 on:** August 24, 2015, 09:32:48 pm »

Thanks coloradogirl. I live primarily in the south so if the market goes south no big deal, for us. Doesn't help my work and second home in Montana though.

In recent weeks I've been having longer and longer flashes of what it once meant to be normal, not sick with that insidious illness which is the chronic inflammatory state of hepatitis c. I'm even beginning to remember what it felt like to have plans and dreams for the future. Something I must have lost over time. So gradually I hardly noticed. Psychological or physical, likely both. In any case the future seems to open up as a place of possibilities, not a place of progressive illness. Odd thing that, after all this time.

Phil

opaleye · « **Reply #540 on:** August 25, 2015, 09:33:57 am »

Congrats to all the Undetected!!!

Harvoni might not slay all the dragons but it surely is a much sharper sword than the previous weapons!

@Barbara, No, I never did have an Undetected result. My doctor considered > 15 Detected as "negative" since, as the PA said, 'everyone who is > 15 during treatment clears the virus after treatment.' Well, almost everyone. I also was their only patient who reported numerous side effects. I wonder if there is a correlation between side effects and success of the treatment? I had these odd visual disturbances that were a rare reaction to Sovaldi. I wonder if that sensitivity to Solvaldi meant it wasn't effective?

I had my primary doctor run labs for liver functions. My AST/ALT numbers were about 10 points higher than before Harvoni. (They have remained steady for the last decade.) So, my viral load got knocked down significantly but damage is still being done. Maybe even a bit worse than before.

Has anyone heard anything about options for Harvoni Relapsers? I wonder I should ask my insurance company about Viekira Pak?

Congrats again to all the responders!!

~opaleye

mario555 · « **Reply #541 on:** August 25, 2015, 10:02:59 am »

Opaleye. I am really sorry to hear about your relapse. Here are my thoughts about the treatment.

Harvoni has Sovaldi as a "nuke". This product is the "magic" component in the pill. You haven't cleared the virus during your whole treatment, it never came down to UND. My feeling is that a longer treatment would not work, you don't seem to respond to that product. You are right in saying that this is the 1st known case like that. I would therefore not try Sovaldi combination again.

You could go with Viekira packs. I know they use a different "nuke" (nucleotide) to fight the disease. You might have better luck. Unfortunately, Viekira seems to be harder to take and has more side effects than Harvoni.

You could also wait to see what other companies are coming up with in the next 18 months. Mercks, Regeneron, etc, have products close to being ready. Given the fact you seem to have a little bit of time to check things out (level of fibrosis).

I would suggest you wait a bit so as not to get into another treatment based on panic or rebound. If you search and investigate the new products, compare their results, pack up some cash and get into your new future treatment well armed, you might be more successful the next time around . It is really easy for me to say that, I am not in your position! Also, don't let insurance companies determine lengths of treatment for you! The 8 weeks treatment sounds good but, for the other who failed, it's a major problem! Best of luck to you...

gnatcatcher · « **Reply #542 on:** August 25, 2015, 11:20:48 am »

Quote from: opaleye on August 25, 2015, 09:33:57 am

. . . No, I never did have an Undetected result. My doctor considered > 15 Detected as "negative" since, as the PA said, 'everyone who is > 15 during treatment clears the virus after treatment.' Well, almost everyone. I also was their only patient who reported numerous side effects. . . .
Has anyone heard anything about options for Harvoni Relapsers? . . .

Opaleye, I am very sorry that you not only suffered numerous side effects but also did not clear the virus. Lynn K answered someone else's question about options for Harvoni relapsers here: http://forums.hepmag.com/index.php?topic=3160.msg26371#msg26371

As Mario wrote, many new treatments are nearing approval (see http://www.hepmag.com/articles/hepatitis_c_drugs_2502_27568.shtml for more info). I hope your hepatologist will be able to guide you to a treatment that will cure you.

opaleye · « **Reply #543 on:** August 25, 2015, 01:36:01 pm »

@ Mario and gnatcatcher,

Thanks so for the advice and information. I waited over a decade for a better treatment, what's another year or two, right?

~opaleye

GLCII · « **Reply #544 on:** August 25, 2015, 01:39:37 pm »

I just got back 3 of the 4 tests I had done for my 12 week post TX. Though the one I'm most interested in is the HEPATIC FUNCTION PANEL posted below. These numbers make me feel pretty good about the HEPATITIS C QUANT RNA PCR that will be here in a couple days. I'm amazed at how hard it is to click open the results when they arrive. Just before clicking open the results, my heart started racing.

AST/SGOT <35 IU/L 19

ALT/SGPT <78 IU/L 19

PROTEIN TOTAL 6.0 - 8.3 g/dL 7.7

Albumin 3.7 - 4.8 g/dL 3.4

Bilirubin, Total <1.2 mg/dL 0.3

Bilirubin, Direct 0 - 0.3 mg/dL 0.1

Alkaline Phosphatase <130 IU/L 75

Globulin 2.5 - 4.1 g/dL 4.3

WaltFrazier · « **Reply #545 on:** August 25, 2015, 03:06:25 pm »

Its been awhile since I am been on the board But....Just found out SVR 13 because I was away.... is Undetected. I am CURED!!!!!! The most amazing feeling in the world. After the previous failure of over a year interferon and the 12 week harvoni....Speechless...

1. 4wk EOT VL: Undetectected
2. 8wk EOT VL: Undetectected
3. Treatment duration-12 weeks Harvoni
4. Previously Relapsed after 62 weeks on Interferon/ribravarin 2007
5. Genotype 1a
6. fibrosis status--F2-F3 (Jan 2015)
7. Initial VL (2.5million))

Imbb · « **Reply #546 on:** August 25, 2015, 03:11:23 pm »

Opaleye, So sorry. Please don't be offended but I was somewhat relieved that it wasn't really a relapse but a failure to clear the virus. Some failure of the drug to work with your body chemistry perhaps. Each relapse unnerves me, as I could be next. I can't follow your footsteps as I am not detected. Hoping to stay that way.

I was surprised to read the suggestion that <15 detected was considered negative, all my results say <15, then not detected. Don't know what to make of any of it but agree with Mario, a low level of fibrosis can allow you to buy time for the next round of new treatments. Personally I would not go with any option for harsher side effects unless I absolutely had to. And the years go by mighty fast these days....

mario555 · « **Reply #547 on:** August 25, 2015, 03:31:57 pm »

Walt. Congratulations! Hope you kicked it good! It sure is a nice surprise! You come back from vacation, go to work, get cured! Super!

Just a little question... When you say relapse after 62 weeks, was it 62 weeks after End Of Treatment?? or right after you stopped treatment? I remember my shit times on Inf and I am curious...

Camper · « **Reply #548 on:** August 25, 2015, 05:57:34 pm »

I have had my blood test 5 wks. after treatment and virus was undetected. In 8 wks. I will have my last hoping for virus to be undetected and cured. Opaleye sorry you were not cured but there is some good news. I had my treatment through the VA and was cared for during treatment by a pharmaceutical doctor. I was told by her they are working on a one pill treatment one pill and hopefully cured. I think that better and more successful treatments will be soon available. Think positive and do your best to care for your liver until a better treatment becomes available.It took me 14 wks. to become undetected and took harvoni for a total of 21 wks. I was suppose to take it for 24 wks. but my eyes became swollen, sore and very blurry. So treatment was stopped because of concern for my eyesight and a eye exam was scheduled. Now I am very tired in ways than I was not before treatment. The medicine seems to of affected everyone differently.

Mugwump · « **Reply #549 on:** August 25, 2015, 06:07:36 pm »

Quote from: mario555 on August 25, 2015, 03:31:57 pm

Walt. Congratulations! Hope you kicked it good! It sure is a nice surprise! You come back from vacation, go to work, get cured! Super!

Just a little question... When you say relapse after 62 weeks, was it 62 weeks after End Of Treatment?? or right after you stopped treatment? I remember my shit times on Inf and I am curious...

Mario for me it was the same back at the end of 2004, it was not until long after the 48 week treatment that I was finally confirmed as having relapsed so the months of hope very quickly turned to despair in my case and I am sure Walt went through the same hell as I did after being so close to a cure back then. It was torture to say the least not having more frequent VL testing because of the high costs of tests!

opaleye · « **Reply #550 on:** August 25, 2015, 07:24:28 pm »

Quote from: Imbb on August 25, 2015, 03:11:23 pm

Opaleye, So sorry. Please don't be offended but I was somewhat relieved that it wasn't really a relapse but a failure to clear the virus. Some failure of the drug to work with your body chemistry perhaps. Each relapse unnerves me, as I could be next. I can't follow your footsteps as I am not detected. Hoping to stay that way.

I was surprised to read the suggestion that <15 detected was considered negative, all my results say <15, then not detected. Don't know what to make of any of it but agree with Mario, a low level of fibrosis can allow you to buy time for the next round of new treatments. Personally I would not go with any option for harsher side effects unless I absolutely had to. And the years go by mighty fast these days....

I'm not offended at all. I just called it "relapsed" because that's what the nurse called it. While I was on Harvoni and got the < 15 Detected results, I did some research and according to these studies, most people did clear the virus even if a few were detected at EOT. So, when my doctor said he considered that "negative" I figured he was reading the same studies.

Thanks so much for the encouragement, and congrats on being undetected!

~opaleye

opaleye · « **Reply #551 on:** August 25, 2015, 07:27:00 pm »

Quote from: WaltFrazier on August 25, 2015, 03:06:25 pm

I am CURED!!!!!! The most amazing feeling in the world. After the previous failure of over a year interferon and the 12 week harvoni....Speechless...

So wonderful to hear these success stories!!

opaleye · « **Reply #552 on:** August 25, 2015, 07:30:09 pm »

Quote from: Camper on August 25, 2015, 05:57:34 pm

I have had my blood test 5 wks. after treatment and virus was undetected. ... I was told by her they are working on a one pill treatment one pill and hopefully cured. I think that better and more successful treatments will be soon available.

Congrats on being undetected!! Thanks so much for the encouragement and the news about this "one magic pill."

opaleye · « **Reply #553 on:** August 25, 2015, 07:32:23 pm »

Quote from: opaleye on August 21, 2015, 01:59:50 pm

1. 4 wk EOT VL: not tested
2. 15 wk EOT VL: ~ 170,000
3. Treatment duration-8 weeks
4. tx naive
5. Genotype 1a
6. fibrosis status--FibroSure F1-2 A2 (Oct 2014)
7. Initial VL 2,812,380 (Oct 2014)

Correction (sorry for the typo): 2. 15 wk EOT VL: ~ 670,000

WaltFrazier · « **Reply #554 on:** August 26, 2015, 09:12:43 am »

Mario sorry. I was referring to interferon/ribr treatment on 07'. The virus came back after completing 48 week treatment. so effectively 14 weeks after treatment ended! Couldn't sleep last night, was crying which were tears of happiness. After this long difficult journey its gone. I felt sad, glad emotions were racing through my head. But I didn't mind not sleeping and just gong through these emotions!. Best success to everyone and this group has been tremendous support and guidance helping me with this fear of taking Harvoni and if I would be cured. It works if you work it!!!!!!!!!!!

mario555 · « **Reply #555 on:** August 26, 2015, 12:26:19 pm »

Walt. You answered the question perfectly. I just can't imagine the despair to see that f...ing virus coming back 16 weeks later! During my Inf treatment, the virus was back right after. I didn't get a chance to be happy, just more bad news after an awful treatment!
As for your happiness right now, you're doing better than me! Even after being UND 12, I still don't trust my results. Did they do the test properly? Will it come back? Why don't I have more energy? How long will my side effects after treatment last?
I am an accountant so I have a professional bias. Everybody lied to me during tax season. So, I need a lot of proof before declaring myself satisfied! I guess this bias is showing all over my life!
In any case, I'm happy for you and wish you the best of luck for the future!

WaltFrazier · « **Reply #556 on:** August 26, 2015, 12:47:48 pm »

Mario, Trust yourself and your doctors. You deserve to be hep C free! Stay present. Today you are Hep C free! Enjoy the happiness and today! I too had some distrust. I let it go and believe what they said. I deserve to be HepC free and I am. Best of luck and love yourself today....

KimInTheForest · « **Reply #557 on:** August 26, 2015, 12:51:08 pm »

Quote from: WaltFrazier on August 26, 2015, 12:47:48 pm

Mario, Trust yourself and your doctors. You deserve to be hep C free! Stay present. Today you are Hep C free! Enjoy the happiness and today! I too had some distrust. I let it go and believe what they said. I deserve to be HepC free and I am. Best of luck and love yourself today....

Great attitude and great advice, Walt!

kim

Bob V · « **Reply #558 on:** August 26, 2015, 04:50:00 pm »

Hi guys
I haven't logged into the forum in several weeks, sorry but I got my 24wk post lab results.

Not detected!!

I'll have to do some catching up on the posts.

1. 4wk - 12 wk after EOT VL status UND!
2. Treatment duration: 12wks
3. tx naive or experienced: Experienced
4. Genotype (1a or 1b) 1a
5. F1-F4 fibrosis status (date): not done
6. Initial VL (date): Pre Tx 3.7m, dx early 90's
12wk post TX lab UND!
24wk post TX lab UND!

gnatcatcher · « **Reply #559 on:** August 26, 2015, 05:02:01 pm »

Great news, Bob! While you were away from the forum, Mugwump/Eric started a separate thread called "Harvoni 24 week EOT results check." I hope you will post there (http://forums.hepmag.com/index.php?topic=3205.0) as well.

Bob V · « **Reply #560 on:** August 26, 2015, 05:07:26 pm »

gnatcatcher
Thanks I'll check in over there too

WaltFrazier · « **Reply #561 on:** August 26, 2015, 06:39:50 pm »

Mugwump....Thanks for your empathy. I know you. You experienced the same disappointment when relapsing years ago. It was Hell. I thought I was going to die from the meds but persevered because I wanted the cure. So akll that makes this so much sweeter and I am grateful I had another opportunity and it worked. Thanks all.

apache · « **Reply #562 on:** August 26, 2015, 06:53:37 pm »

Got my SVR12 notice today

Thus ends a 43 year problem, brought on by a blood transfusion at 8 years old.
If someone is still collecting stats, here's mine:
1. 12 wks after EOT VL status: UND (SVR12)
2. Treatment duration: 3 months (was initially scheduled for 2)
3. tx naive or experienced: naive
4. Genotype (1a or 1b): 1a
5. F1-F4 fibrosis status (date): F1
6. Initial VL (date): 2.9 million right before started Harvoni

coloradogirl · « **Reply #563 on:** August 26, 2015, 07:33:49 pm »

Yay, Apache! So happy for you!

coloradogirl · « **Reply #564 on:** August 26, 2015, 07:36:15 pm »

Quote from: mario555 on August 26, 2015, 12:26:19 pm

Walt. You answered the question perfectly. I just can't imagine the despair to see that f...ing virus coming back 16 weeks later! During my Inf treatment, the virus was back right after. I didn't get a chance to be happy, just more bad news after an awful treatment!
As for your happiness right now, you're doing better than me! Even after being UND 12, I still don't trust my results. Did they do the test properly? Will it come back? Why don't I have more energy? How long will my side effects after treatment last?
I am an accountant so I have a professional bias. Everybody lied to me during tax season. So, I need a lot of proof before declaring myself satisfied! I guess this bias is showing all over my life!
In any case, I'm happy for you and wish you the best of luck for the future!

So you know Mario, for every debit, there must be a credit! Give yourself credit, and believe you are cured. Hugs, brother!

mario555 · « **Reply #565 on:** August 26, 2015, 09:00:08 pm »

Colorado girl. Well answered and real cute!
I just saw your statistics at the bottom of your post. You're a newbie to this new hep c free life! You seem to be in very good spirits soon after your good news. Nice to see!
It's been 3 - 4 days where I have felt recurring side effects and my tinnitus hampers my life (restaurants, noisy places, etc). I think I overdosed myself with 24 weeks of treatment.
Anyway, I guess I prefer to deal with this than the hep c virus! Good luck to you and thanks again for the uplifting comment!

Bob V · « **Reply #566 on:** August 26, 2015, 10:41:52 pm »

Just read the posts from the last few weeks, congrats to all that reached SVR.

Some bummer posts too

opaleye
So sorry, gotta suck for you but you seem to have a good attitude....better then I would. Good luck and the stock marked kinda recovered.

PintoLady · « **Reply #567 on:** August 27, 2015, 01:45:47 pm »

Just got my results this morning and want to join in. I am new to this or any forum. May have contacted this virus in 1967 when I received blood during an operation at age 15.

My stats:
1) 12 weeks on Harvoni + Ribavirin Finished June 2
2) Treatment experienced, 3 times non-responder, 2005, 2008, 2011
3) Genotype 1A
4) FibroScan F2 3-2015, Fibrospect F2-F4 6-2014
5) HCV Load 7,686,524 on 3-2015
6) 4 week and 12 week after treatment Undetected

KimInTheForest · « **Reply #568 on:** August 27, 2015, 01:47:52 pm »

Congratulations on being cured, PintoLady! And welcome to the forums.

And congrats to all others who have posted their good news here!

Wellness to all,
kim

GLCII · « **Reply #569 on:** August 27, 2015, 06:05:42 pm »

Got my 12 Week Post EOT result today. I thought it would be more of a climatic moment.

HCV RNA Not detected. I guess not everything can be associated with sex! $:-\$

1. 12 week EOT status – SVR12
2. Treatment Duration - 12 weeks Harvoni
3. tx naive or experienced - experienced
4. Genotype (1a or 1b) – 1a
5. F1-F4 fibrosis status (date) – F2/F3
6. Initial VL – 12043488 mil

AST/SGOT <35 IU/L 19
ALT/SGPT <78 IU/L 19

PROTEIN TOTAL 6.0 - 8.3 g/dL 7.7
Albumin 3.7 - 4.8 g/dL 3.4
Bilirubin, Total <1.2 mg/dL 0.3
Bilirubin, Direct 0 - 0.3 mg/dL 0.1
Alkaline Phosphatase <130 IU/L 75
Globulin 2.5 - 4.1 g/dL 4.3
AFP, Non-Maternal <8.1 ng/mL 3.7

HCV results (IU) HCV RNA Not detected.

Bob V · « **Reply #570 on:** August 27, 2015, 06:59:25 pm »

Congrats to PintoLady and CLCll, enjoy the feeling

opaleye · « **Reply #571 on:** August 27, 2015, 07:30:13 pm »

Quote from: GLCII on August 27, 2015, 06:05:42 pm

Got my 12 Week Post EOT result today. I thought it would be more of a climatic moment. HCV RNA Not detected.

Woo Hoo!!

Congrats to you and PintoLady!

Katie · « **Reply #572 on:** August 29, 2015, 01:37:23 am »

Hey everyone. Just got my 24 post treatment week ALL CLEAR RESULTS! YAY...the nurse called me with the results and I am still Undetected. I was confident that it was OK but it is always good to hear. I will get the copy this coming Wednesday along with related blood work.

I just keep singing

GOOD BYE BIO HAZARD~HELLO LIFE!

I figured it is good to share and build up everyone's confidence that Harvoni truly ROCKS and for you to move forward. May all of you warriors keep up the fight and WIN the battle!

Bless you all!

Katie

GLCII · « **Reply #573 on:** August 29, 2015, 03:44:37 am »

Congratulations Kate!!!

Philadelphia · « **Reply #574 on:** August 29, 2015, 04:46:26 am »

Congrats to all who are undetected. Such great news.

gnatcatcher · « **Reply #575 on:** August 29, 2015, 05:36:12 am »

Fabulous, Katie! I hope you'll also post the great news to the newish thread Mugwump/Eric started called "Harvoni 24 week EOT results check": http://forums.hepmag.com/index.php?topic=3205.0 You'll make it SEVEN out of SEVEN who have achieved SVR24!

dragonslayer · « **Reply #576 on:** August 29, 2015, 09:48:29 am »

Fantastic News, Katie! I knew you would do it!!!

tm · « **Reply #577 on:** August 29, 2015, 10:09:02 am »

Got the call yesterday nurse said that I am CURED twelve weeks after treatment!

was 1b
12 wks harvoni
2 prior failed treatment
f0 f1

I have been truly blessed. I feel great lots of energy. I am ready to start my new life.
So happy for all that have cleared, and hopeful for new treatments for those who have not. The cure ended up costing me only $5.00, life is good!

gnatcatcher · « **Reply #578 on:** August 29, 2015, 11:02:25 am »

tm, I'm so glad "the third time's the charm" is true for you. Have a wonderful new life.

Patience · « **Reply #579 on:** August 29, 2015, 07:15:24 pm »

Great news, Katie! And tm, I love how you posted "was 1 b"! I took my final Harvoni 2 hours ago and I'm am hoping I WAS 1b also!

Katie · « **Reply #580 on:** August 29, 2015, 07:26:24 pm »

Thanks again for all of the good wishes. You guys are terrific and you helped me through this so much.

It's been great to get to know so many of you on this forum and I'll still be around offering any support or input that I can!

Big {{{{HUGS}}}} to all of you!

Katie

Bob V · « **Reply #581 on:** August 29, 2015, 10:11:41 pm »

Fantastic news Katie and TM

Lynn K · « **Reply #582 on:** August 30, 2015, 04:04:24 am »

Congrats to you both Katie and TM!

concerned father · « **Reply #583 on:** August 31, 2015, 08:45:46 am »

My 20 year old daughter who was infected by her birthmother at birth will start her 12 week treatment tomorrow. I'm hoping for SVR.

Bob V · « **Reply #584 on:** August 31, 2015, 10:47:46 am »

Concerned father

Wishing your daughter the best of luck with her treatment.

concerned father · « **Reply #585 on:** August 31, 2015, 10:57:07 am »

Quote from: Bob V on August 31, 2015, 10:47:46 am

Concerned father

Wishing your daughter the best of luck with her treatment.

Thanks

katmakiah · « **Reply #586 on:** August 31, 2015, 12:13:16 pm »

1. 12 wk AFTER EOT VL status 1.5 million (was Undie at EOT, It came back after that, before the final test.)
2. Treatment duration - 12 weeks
3. tx naive or experienced - naive
4. Genotype (1a or 1b) - 1A
5. F1-F4 fibrosis status (date) - F-4 Feb '11
6. Initial VL (date) 2.7 mil, Dec '14

mario555 · « **Reply #587 on:** August 31, 2015, 12:34:24 pm »

Katmakia. I am totally sorry for your relapse. You seem to take the news real well and with the new medication coming out, I know you will find something that will rid you of this terrible disease!
I went into your old posts and you are the first case that I know about who relapsed between week 4 and week 12. I thought once you cleared week 4 undetected, that it was over. I stand corrected!

concerned father · « **Reply #588 on:** August 31, 2015, 12:39:22 pm »

Katmakia, Sorry to hear that. Did you change your tooth brush and razors on regular basis during the treatment?

katmakiah · « **Reply #589 on:** August 31, 2015, 01:58:44 pm »

mario, I was undetected at end of the 12 week treatment. I relapsed after that, some time before the 12 week after end of treatment labs. Which would be 24 weeks from start of treatment.

Quote from: mario555 on August 31, 2015, 12:34:24 pm

Katmakia. I am totally sorry for your relapse. You seem to take the news real well and with the new medication coming out, I know you will find something that will rid you of this terrible disease!
I went into your old posts and you are the first case that I know about who relapsed between week 4 and week 12. I thought once you cleared week 4 undetected, that it was over. I stand corrected!

katmakiah · « **Reply #590 on:** August 31, 2015, 02:01:04 pm »

Oh, absolutely, dad.

I changed my toothbrush every 2 weeks. Didn't use any razors. Also tossed any needles I used to dig out splinters. Have not put any pierced earrings on. Tossed tweezers, nail clippers and scissors as well, that may have come into contact with blood.

Quote from: concerned father on August 31, 2015, 12:39:22 pm

Katmakia, Sorry to hear that. Did you change your tooth brush and razors on regular basis during the treatment?

Bob V · « **Reply #591 on:** August 31, 2015, 03:09:29 pm »

katmakish
Sorry about the relapse, sounds like you did everything correct. I really don't know what else to say but I hope the newer drugs coming out work for you.

Katie · « **Reply #592 on:** August 31, 2015, 03:22:00 pm »

katmakish: When one of our group has a relapse, we all feel your pain. So sorry but stay strong and move forward. There is lots of research and new things right around the corner so continue taking care of yourself and stay informed. You will win this battle.

I send you a {{{{BIG HUG}}}}

Katie

Mugwump · « **Reply #593 on:** August 31, 2015, 03:28:17 pm »

Quote from: concerned father on August 31, 2015, 12:39:22 pm

Katmakia, Sorry to hear that. Did you change your tooth brush and razors on regular basis during the treatment?

I really think the best solution to the tooth brush question is not to worry about it. I changed out after I got my first <15 vl reading. But as the TX progressed I simply went to 4 brushes that I allowed to dry out in rotation. And I used food grade hydrogen peroxide solution on them after use. So there is no way that they could have been a problem.

Over the years I am also sure that the worries about towels and all the other precautions that us HCV victims have fretted about are much overblown. If transmission by these means was common then HCV would be a pandemic of monumental proportions. I am not trying to lighten the seriousness of the disease in any way. But there is far too much concern over this aspect of living with the disease.

For all the years that I did not know that I had the infection I did not infect the people who used the same towels, shared razors at times, showered together and had contact that is natural and human.

Yes be concerned during treatment about reinfect but the chances of this happening are very, very slight if there are no other mitigating circumstances like ongoing drug use with infected partner(s) or other self destructive behaviour to consider.

I am sure your daughter will clear this disease and be free from the life of worry that every little cut, use of a towel, trip to a dentist or medical procedure brings.

Mugwump · « **Reply #594 on:** August 31, 2015, 03:44:51 pm »

@katmakia Going forward after finding out the news is difficult. This trial holds some hope because the agent in combination with solvoldi seems to be more effective than ledipasvir.
https://clinicaltrials.gov/ct2/show/NCT02378935?term=Gilead+%26+Hepatitis+C&recr=Open&no_unk=Y&rank=3
I know I would see about enrolling if my treatment failed. Part of the study is for failed TX with cirrhosis so the study is for all circumstances and does not leave out any levels the way some studies do.

All the best
Eric

Bob V · « **Reply #595 on:** August 31, 2015, 04:08:21 pm »

Quote from: Mugwump on August 31, 2015, 03:28:17 pm

I really think the best solution to the tooth brush question is not to worry about it. I changed out after I got my first <15 vl reading. But as the TX progressed I simply went to 4 brushes that I allowed to dry out in rotation. And I used food grade hydrogen peroxide solution on them after use. So there is no way that they could have been a problem.

Over the years I am also sure that the worries about towels and all the other precautions that us HCV victims have fretted about are much overblown. If transmission by these means was common then HCV would be a pandemic of monumental proportions. I am not trying to lighten the seriousness of the disease in any way. But there is far too much concern over this aspect of living with the disease.

For all the years that I did not know that I had the infection I did not infect the people who used the same towels, shared razors at times, showered together and had contact that is natural and human.

Yes be concerned during treatment about reinfect but the chances of this happening are very, very slight if there are no other mitigating circumstances like ongoing drug use with infected partner(s) or other self destructive behaviour to consider.

I am sure your daughter will clear this disease and be free from the life of worry that every little cut, use of a towel, trip to a dentist or medical procedure brings.

Excellent post.

Lynn K · « **Reply #596 on:** August 31, 2015, 07:58:08 pm »

Quote from: concerned father on August 31, 2015, 12:39:22 pm

Katmakia, Sorry to hear that. Did you change your tooth brush and razors on regular basis during the treatment?

Just to chime in I only changed my tooth brush at the interval recommended by my dentist at 3-4 months of use so I did change my brush once on treatment. I also don't shave but still have the same fingernail clippers I started treatment with.

As Mugwump said "the chances of this happening are very, very slight"

Good luck to your daughter on treatment I also am sure she will be fine,

Lynn

Lynn K · « **Reply #597 on:** August 31, 2015, 08:09:53 pm »

Quote from: katmakiah on August 31, 2015, 12:13:16 pm

1. 12 wk AFTER EOT VL status 1.5 million (was Undie at EOT, It came back after that, before the final test.)
2. Treatment duration - 12 weeks
3. tx naive or experienced - naive
4. Genotype (1a or 1b) - 1A
5. F1-F4 fibrosis status (date) - F-4 Feb '11
6. Initial VL (date) 2.7 mil, Dec '14

Hi Katmakiah

Also so sorry to hear of your relapse. When I relapsed last year after treating with Sovaldi and Olysio being not detected on treatment and being found to have relapsed at 12 weeks post test I was crushed. My heart goes out to you and wishing you the best.

Is retreating with 24 weeks of Harvoni with Ribavirin being considered for you?

Hugs to you
Lynn

please see the latest AASLD HCV Guidance:
Recommendations for Testing, Managing, and Treating Hepatitis C

RETREATMENT OF PERSONS IN WHOM PRIOR THERAPY HAS FAILED

http://www.hcvguidelines.org/full-report/retreatment-persons-whom-prior-therapy-has-failed

About half way down the page the report states in the highlighted new text revised Aug 7th:

"Recommended regimen for patients in whom previous treatment with any HCV nonstructural protein 5A (NS5A) inhibitors has failed (including daclatasvir plus sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ritonavir/ombitasvir plus dasabuvir)."

"For patients with minimal liver disease, deferral of treatment is recommended, pending availability of data."

"Rating: Class IIb, Level C"

"For patients with cirrhosis or other patients who require retreatment urgently, testing for resistance-associated variants that confer decreased susceptibility to NS3 protease inhibitors and to NS5A inhibitors is recommended. The specific drugs used in the retreatment regimen should be tailored to the results of this testing as described below. Treatment duration of 24 weeks is recommended and, unless contraindicated, weight-based RBV should be added."

"Rating: Class IIb, Level C"

"For patients with cirrhosis or other patients who require retreatment urgently, testing for RAVs that confer decreased susceptibility to NS3 protease inhibitors (eg, Q80K) and to NS5A inhibitors should be performed using commercially available assays prior to selecting the next HCV treatment regimen. For patients with no NS5A inhibitor RAVs detected, retreatment with ledipasvir/sofosbuvir and RBV for 24 weeks is recommended. For patients who have NS5A inhibitor RAVs detected and who do not have NS3 inhibitor RAVs detected, treatment with simeprevir, sofosbuvir, and RBV for 24 weeks is recommended. For patients who have both NS3 and NS5A inhibitor RAVs detected, retreatment should be conducted in a clinical trial setting, as an appropriate treatment regimen cannot be recommended at this time."

"No data are yet available on the retreatment of patients for whom prior treatment with PrOD has failed. However, studies that have evaluated patients whose virus did not respond to PrOD have reported the presence of RAVs that confer decreased susceptibly to NS3 protease inhibitors (eg, paritaprevir), NS5A inhibitors (eg, daclatasvir, ledipasvir, ombitasvir), and nonnucleoside polymerase inhibitors (eg, dasabuvir). Based on these observations, patients for whom treatment with PrOD did not result in an SVR should have HCV treatment deferred in the setting of mild liver disease, and for those with advanced fibrosis, testing for RAVs should be performed."

"Data on the retreatment of patients for whom prior treatment with ledipasvir/sofosbuvir has failed are very limited. In a pilot study, 41 patients with and without cirrhosis who did not achieve an SVR with 8 weeks or 12 weeks of ledipasvir/sofosbuvir were retreated with 24 weeks of ledipasvir/sofosbuvir. SVR12 rates varied according to the presence or absence of NS5A inhibitor RAVs. Among 11 patients for whom NS5A inhibitor RAVs were not detected, SVR occurred in 11 of 11 (100%); in contrast, among 30 patients for whom NS5A inhibitor RAVs were detected, SVR occurred in 18 of 30 (60%). Importantly, NS5B inhibitor RAVs (eg, S282T) known to confer decreased activity of sofosbuvir were observed in 3 of 12 (25%) patients for whom the retreatment regimen was not successful. Similarly, in the OPTIMIST-2 study in which patients with cirrhosis were treated with simeprevir and sofosbuvir, the presence of NS3 RAVs, namely the Q80K polymorphism, led to a decreased SVR rate in patients with HCV genotype 1a infection. SVR occurred in 25 of 34 (74%) patients with HCV genotype 1a and the Q80K RAV and in 35 of 38 (92%) patients with HCV genotype 1a without the Q80K RAV. Based on these data, retreatment for patients for whom an NS5A inhibitor-containing regimen has failed should be considered in the context of retreatment urgency and the presence or absence of RAVs to inhibitors of NS3 and NS5A. Further, based on limited data, RBV is recommended as part of all retreatment regimens for patients in whom prior treatment with NS5A inhibitors has failed. Although no data exist, consideration may also be given to the addition of PEG-IFN to the retreatment regimen in patients who are eligible for this agent; PEG-IFN will have antiviral activity regardless of the RAVs present."

concerned father · « **Reply #598 on:** September 01, 2015, 07:31:48 am »

Quote from: Mugwump on August 31, 2015, 03:28:17 pm

I really think the best solution to the tooth brush question is not to worry about it. I changed out after I got my first <15 vl reading. But as the TX progressed I simply went to 4 brushes that I allowed to dry out in rotation. And I used food grade hydrogen peroxide solution on them after use. So there is no way that they could have been a problem.

Over the years I am also sure that the worries about towels and all the other precautions that us HCV victims have fretted about are much overblown. If transmission by these means was common then HCV would be a pandemic of monumental proportions. I am not trying to lighten the seriousness of the disease in any way. But there is far too much concern over this aspect of living with the disease.

For all the years that I did not know that I had the infection I did not infect the people who used the same towels, shared razors at times, showered together and had contact that is natural and human.

Yes be concerned during treatment about reinfect but the chances of this happening are very, very slight if there are no other mitigating circumstances like ongoing drug use with infected partner(s) or other self destructive behaviour to consider.

I am sure your daughter will clear this disease and be free from the life of worry that every little cut, use of a towel, trip to a dentist or medical procedure brings.

Thank you Mug.

KimInTheForest · « **Reply #599 on:** September 01, 2015, 01:34:33 pm »

Hi all. So great to see so many victories here! My heart goes out to those who did not achieve SVR12. There will be future chances!

I know this thread was started for Geno 1 people on Harvoni. And I am/was Geno 3a on Harvoni+Riba. But I wanted to share my results here too. There are a number of Geno 3 people (and probably other Geno's as well) on Harvoni. Right now in Canada a clinical trial involving 100 Geno 3's is underway involving Harvoni+Riba. I am not the only forum member participating in that trial. So since I just achieved SVR4, here are my deets:

1. 4 weeks post-treatment (Aug-25-2015): HCV Undetected
2. 12 weeks (Harvoni+ribavirin)
3. tx naive
4. Genotype 3a
5. Fibroscan: F2 (8.5 kPa) (Apr-16-2015)
6. Initial VL: 4 million (May-5-2015; day 1 of tx)

kim

Forums Index

Welcome

Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE! (Read 755916 times)